From Significance of the study to Public health relevance:
Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) bio-molecules that drive metastatic process; and the the way to prevent their expression; (ii) a way to activate immune system to combat cancer (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.
Research findings to Therapeutic opportunity:
A number of studies suggests that Kaemphferol prevents tumor growth. However, the mechanism of action is far from clear.
Fig1. Mechanistic insights into how Kaempherol functions as an anti-metastasis agent
This study suggests that Kaemphferol, by increasing the expression of its target genes, it may decrease the expression of metastasis promoter PMP22 (fig. 1).
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Thereby, it may inhibit migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “Kaemphferol or its analogs either alone or in combination with other anticancer drugs” may be used to inhibit the progression of invasive tumors.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $2
Undisclosed information: How Kaemphferol decreases the expression of metastasis promoter PMP22
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
References:
Citation: Boominathan, L., Natural product-derived therapy for Metastatic cancers: Kaempherol, one of the main components of Aloe vera, decreases the expression of PPM22 and inhibits migration, invasion and metastasis of cancer cells via up regulation of its target gene, 11/March/2017, 6.27 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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