What we say:
Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Salvianolic acid B, isolated from Salvia Miltiorrhiza Bunge, promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 28/March/2017, 10.08 am
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From Significance of the study to Public health relevance:
Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) diabetic disease results in a number of health complications, including diabetic cardiomyopathy (DCM), diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy; (3) one third of people with diabetes suffer from diabetic kidney disease (DKD); and one third of them will develop kidney failure; (4) Diabetes is going to be one of the top 10 causes of death by 2030; (5) the life-long painful injection/drug treatment is required to treat DM; (6) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.
From Research findings to Therapeutic opportunity:
This study suggests, for the first time, that Salvianolic acid B, by increasing the expression of its target gene, it may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote regenerative capacity; (4) promote insulin sensitivity; (5) decrease myocardial infarct size; and (6) inhibit diabetic cardiomyopathy (DCM).
Figure 1. Mechanistic insights into how Salvianolic acid B functions as an anti-hyperglycemic/cardioprotective agent. Salvianolic acid B, by increasing the expression of reprogramming protein Lin-28, IGFIR, INSR, and IRS2 among others, it may promote insulin sensitivity and protect from diabetic cardiomyopathy.
Thus, pharmacological formulations encompassing “Salvianolic acid B or its analogues either alone or in combination with other drugs” may be used to treat DM and DCM.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $ 300#
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Undisclosed mechanistic information: How does Salvianolic acid B promote insulin-sensitized state?
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References:
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Citation: Boominathan L, Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Salvianolic acid B, isolated from Salvia Miltiorrhiza Bunge, promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 28/March/2017, 10.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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