What is known:
It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters”
From research findings to therapeutic opportunity:
This study suggests that N(1), N(11)-Diethylnorspermine, by suppressing the expression of mTOR, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase the lifespan of an individual.
Figure1. N(1), N(11)-Diethylnorspermine may extend mammalian life span via down regulation of mTOR
Together, this study suggests that pharmacological formulations encompassing “N(1), N(11)-Diethylnorspermine or its analogues” may function as longevity promoters.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Amount: $50
Undisclosed mechanistic information: How does N(1), N(11)-Diethylnorspermine increase longevity?
For purchase and payment details, you may reach us at admin@genomediscovery.org
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product Life-span extension therapy: N(1), N(11)-Diethylnorspermine, a spermine analog, may increase life span by suppressing mTOR pathway, 28/November/2016, 11.13 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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# Research cooperation