What is known:
It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters”
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Plum extract, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase the lifespan of an individual.
Figure1. Plums (Prunus salicina L) extract may extend mammalian life span via down regulation of mTOR
Together, this study suggests that pharmacological formulations encompassing “Plum extract or an active compound isolated from it” may function as longevity promoters.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Amount: $50
Undisclosed mechanistic information: How Plum extract decreases the expression of mTOR?
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product Life-span extension therapy: Plums (Prunus salicina L) extract increases life span by suppressing mTOR pathway through up regulation of its target gene, 22/November/2016, 6.10 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org
# Research cooperation