A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Lifespan extension therapy: Kaempferol, found in Aloe vera, Coccinia grandis, Moringa oleifer, Rosmarinus officinalis, among others, increases life span via up-regulation of its target gene BubR1.
Research Findings:
Kaempferol, found in Aloe vera, among others, as indicated below, slows down ageing and increases median lifespan via up-regulation of BuBR1
Kaempferol is found in Coccinia grandis
Kaempferol is found in Rosmarinus officinalis
Moringa Olifera tree. Moringa Olifera extract contains Kaempferol
Kaempferol, by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of ageing; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “Kaempferol or its analogues” may be used to extend the lifespan of an individual.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Natural product Lifespan extension therapy: Kaempferol, found in Aloe vera, Coccinia grandis, Moringa oleifer, Rosmarinus officinalis, among others, increases life span via up-regulation of its target gene BubR1, 23/June/2015, 5.34 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Kaempferol increases the expression of BubR1 and extends life span
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