What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Lifespan extension therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), found in Kalopanax pictus, Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean,increases life span via up-regulation of its target gene BubR1.
From Research Findings to Therapeutic Opportunity:
This study suggests a natural product-based life extension therapy. Methyl 3,5-dicaffeoyl quinate (MDQ), by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing“Methyl 3,5-dicaffeoyl quinate (MDQ) or its analogues” may be used to extend the lifespan of an individual.
Methyl 3,5-dicaffeoyl quinate (MDQ), found in Castor-aralia (kalopanax-pictus), among others, as indicated below, extends mammalian life span via up regulation of BuBR1
Salicornia herbacea L
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $100#
Undisclosed information: How Methyl 3,5-dicaffeoyl quinate (MDQ) increases the expression of BubR1 and extends mammalian life-span
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
# Research cooperation
Reference:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product Lifespan extension therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), found in Kalopanax pictus, Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases life span via up-regulation of its target gene BubR1, 11/November/2016, 10.04 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org