A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension: Olive tree leaf extract inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3
olive tree branch with green olives
Significance: Olive tree leaf extract (also known as Olea europaea leaf extract), by increasing the expression of its target gene, it may decrease the expression of Notch3. Thus, pharmacological formulations encompassing “ Olive tree leaf extract or an active isolated from it” may be used to treat pulmonary arterial hypertension.
Undisclosed information: How Olive tree leaf extract decreases the expression of Notch3
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Natural product therapy for pulmonary arterial hypertension: Olive tree leaf extract inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 18/September/2016, 10.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
# Research cooperation