Reproductive hormone Progesterone 4 (P4) may find its utility in the treatment of anxiety and depression: Progesterone (P4), a reproductive hormone, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 8/August/2018, 9.35 pm