Introduction:What they say:
A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in the 28 September 2016 issue of Cancer Discovery (one of the best journals in Cancer Science with an impact factor of 19+) by Prof Andrea L. Cox, Park BV and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small molecule-based PD-1 pathway blockade for Human cancer therapy: SMG7, a protein known to play a role in nonsense-mediated mRNA decay, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene
What is known?
It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year recently.
From Research Findings to Therapeutic opportunity:
This suggests that SMG7, by decreasing the expression of its target gene, it may suppress the expression of PD-1. Thereby, it may (1) increase the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes; (2) augment antitumor activity of the immune system; & (3) inhibit metastatic cancer progression.
Thus, pharmacological formulations encompassing “SMG7 activators” may be used to inhibit the progression of tumors.
Details of the research findings:
Idea Proposed/Formulated (with factual evidence) by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Amount: $100
Undisclosed information: How SMG7 suppresses the expression of PD-1 and augments anti-tumor immunity
# Research cooperation
References:
Citation: Boominathan, L., Small molecule-based PD-1 pathway blockade for Human cancer therapy: SMG7, a protein known to play a role in nonsense-mediated mRNA decay, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 18/December/2016, 10.29 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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