Significance of the study:
It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Swimming training, by increasing the expression of its target genes, it may decrease the expression of AT1R.
Figure1. Mechanistic insights into how Swimming training functions as a longevity- promoter. Swimming training, by increasing the expression of its downstream target genes, down regulates A1TR expression and promotes longevity.
And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) decelerate ageing process; and (4) extend the lifespan of an individual.
Together, this study suggests, for the first time, that swimming training may decrease blood sugar/pressure levels, inhibit cardiac ageing and extend the lifespan of an individual. Thus, physicians may consider recommending patients suffering from metabolic diseases, including hypertensive patients, to undergo swimming therapy. (Figure 1).
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Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Swimming training suppress the expression of angiotensin II type I receptor (AT1R)?
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# Research cooperation
References:
Citation: Boominathan, L., Swimming as a therapeutic exercise to extend lifespan: Swimming training prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 12/May/2017, 11.58 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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