What we say:
Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A fibrous way to strengthen your heart and extend lifespan: β-glucan-based therapy for cardiomyopathy: β-glucan, found abundantly in oats and barley, may suppress tumor suppressor INK4a/p16 expression, inhibit dilated cardiomyopathy and extend life span, via up regulation of its target gene
From the Significance of the study to Public health relevance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) Dilated cardiomyopathy is the leading cause of Heart failure; (3) the raise of death rate, due to cardiovascular disease, has increased from 12.3 million in 1990 to 17.3 million in 2013; (4) 13% of cardiovascular disease occur due to uncontrolled high blood pressure; (5) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (6) 85% of people over 80 years are susceptible to cardiovascular diseases; (7) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (8) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; and (9) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a cure to diseases, as mentioned above, leading to cardiovascular disease; (ii) a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (iii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.
From research findings to therapeutic opportunity:
This study suggests, for the first time, that β-glucan, by increasing the expression of their target gene, they may increase the expression of oncoprotein BMI-1 and suppress the expression of tumor suppressor and the ageing marker INK4a/p16 (figure 1 ).
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Figure 1. Mechanistic insight into how β-glucan may function as cardioprotective agents. β-glucan inhibit dilated cardiomyopathy and heart failure via down regulation of ageing/senescence marker INK4a
Figure 2. The chemical structures of β-glucan
Thereby, they may: (1) inhibit cardiac senescence; (2) increase of regenerative potential in aged tissues; and (3) improve ventricular dimensions and contractility.
Thus, (1) by encouraging myocardial patients to consume β-glucan, one may prevent Dilated cardiomyopathy and ageing-associated (or, stress-associated) decline in cardiac function; and (2) pharmacological formulations encompassing “β-glucan or its analogues, either alone or in combination with other drugs,” may be used to inhibit dilated cardiomyopathy and heart failure (figure 1). [easy_payment currency=”USD”]
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How β-glucan increases the expression of oncoprotein BMI-1, while decreasing the expression of tumor suppressor INK4a
Amount: $500#
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References:
Web: http://genomediscovery.org or newbioideas.com
Citation: Boominathan, L., A fibrous way to strengthen your heart and extend lifespan: β-glucan-based therapy for cardiomyopathy: β-glucan, found abundantly in oats and barley, may suppress tumor suppressor INK4a/p16 expression, inhibit dilated cardiomyopathy and extend life span, via up regulation of its target gene, 23/May/2018, 12.37 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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