Introduction: What they say:
A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published, in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973], by Drs. Zusen Fan, Xia and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Mechanistic insights into how Vitamin C/Ascorbic acid enhances immunity against bacterial infections: Ascorbic acid-based immune enhancement therapy: Ascorbic acid increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2020, 10.26 am
From Research Findings to Therapeutic Opportunity:
It is known for years that intake of Vitamin-D3/Cholecalciferol augments immunity. However, the mechanistic basis of which largely remains unclear.
This study suggests, for the first time, Cholecaliferol, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in the cytoplasm; and (3) promote innate immunity against bacterial infection.
Figure 1. Vitamin D3-based immune enhancement therapy. Low dose Cholecalciferol (10nM), by increasing the expression of its target genes, it increases the expression of Sox-2 and its downstream components in the signaling pathway. And, thereby, it promotes anti-bacterial immunity.
Figure 2a. Low dose Cholecalciferol/Vitamin-D3 [10nM] increases resistance against bacterial infection through induction of Sox2.
Together, pharmacological formulations encompassing “Cholecalciferol/ or its analog, either alone or in combination with other drugs,” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance (figs. 1-2).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Cholecalciferol enhance innate immunity against bacterial infections?
Amount: $750
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References:
Citation: Boominathan, L., Mechanistic insights into how Vitamin D3/Cholecalciferol enhances immunity against bacterial infections: Cholecalciferol-based immune enhancement therapy: Low dose Cholecalciferol/Vitamin-D3 increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 10/March/2020, 6.18 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
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