Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Anti-metastasis therapy: MiRNA-134 increases the expression of TPM1 (tropomyosin) and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 30/April/2015, 18.19, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: The study presented here suggests that MiRNA-134, by decreasing the expression of its target genes, it may increase the expression of TPM1 (tropomyosin). Thereby, it may inhibit migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing “MiRNA-134 activators” may be used to inhibit the progression of invasive tumors.
Undisclosed information: How MiRNA-134 increases the expression of TPM1
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