A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Stretch therapy for pulmonary arterial hypertension: Mechanical stretch inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3.
Significance: This study suggests, for the first time, that mechanical stretch, by increasing the expression of its target gene, it may decrease the expression of Notch3. Thus, physicians may consider recommending stretch therapy for pulmonary hypertensive patients (Figure 1).
Figure 1. Mechanistic insights into how stretch therapy inhibits the development of Pulmonary Arterial Hypertension (PAH). Figure updation took place on 25/May/2017.
Undisclosed information: How mechanical Stretch decreases the expression of Notch3
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Stretch therapy for pulmonary arterial hypertension: Mechanical stretch inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 1/May/2015, 9.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org