Blood as an anti-diabetic medicine: Autologous blood transfusion-based therapy for TIIDM and obesity-associated metabolic deficits: Autologous blood transfusion increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 15/April/2018, 8.38 pm