Bonding your way to lead a pain-free life: Oxytocin-based activation of the PD-1 pathway for Pain therapy: Oxytocin (also known as compassion/goodness/bonding hormone), a peptide hormone and neuropeptide known to play a role in empathy, generosity, childbirth and so on, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 21/April/2018, 7.07 am