What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the journal “EMBO”, by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Branched-chain amino acids-based Lifespan extension therapy: Branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine) increase life span via up-regulation of its target gene BubR1
From research findings to Therapeutic Opportunity:
This study suggests, for the first time, that Branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine), by increasing the expression of their target genes, they may: (a) increase the expression of BuBR1; (b) regulate the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (Fig. 1).
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Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus, pharmacological formulations encompassing “branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine) or their analogues, either alone or in combination with other drugs,“ may be used to extend the lifespan of an individual (fig. 2).
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $500#
Undisclosed mechanistic information: How a pharmaceutical mix encompassing Branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine) increase the expression of BubR1 and extend mammalian life-span
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# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Branched-chain amino acids-based Lifespan extension therapy: Branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine) increase life span via up-regulation of its target gene BubR1, 27/February/2018, 1.23 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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