Ideas – Page 102

March 25, 2019

Published by admin_auro at March 25, 2019

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Repurposing the antibiotic Ciprofloxacin into a broad-spectrum anti-infective agent: Ciprofloxacin, a drug used to treat bacterial infections, inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 25/March/2019, 8.42 am

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]

March 25, 2019

Published by admin_auro at March 25, 2019

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Intracardiac injection of Hydrogen gas protects against cardiac hypertrophy and fibrosis: Intracardiac or subcutaneous injection or inhalation of Hydrogen gas decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 25/March/2019, 8.22 am

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]

March 25, 2019

Published by admin_auro at March 25, 2019

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Repurposing the anti-bacterial agent Enoxacin into an antiviral agent: Enoxacin-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Enoxacin (Trade names: Comprecin, Enoksetin, Enoxen, Enroxil, Enoxin, Enoxor, Flumark and others), a fluoroquinolone-based antibiotic commonly used in the treatment of urinary tract infections and gonorrhea, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene, 25/March/2019, 7.54 am

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]

March 24, 2019

Published by admin_auro at March 24, 2019

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Ribonucleic acid-based therapy for cardiomyocyte proliferation and heart regeneration: LncRNA ROR decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 24/March/2019, 5.22 pm

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]