Ideas

Natural product-based therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing Fasudil, Epicatechin and Matrine (FEM)  inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 17/January/2018, 11.41 pm
Natural product-based therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing Fasudil, Epicatechin and Matrine (FEM)  inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 17/January/2018, 11.41 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for Cardiovascular Research (DZHK) partner…

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Ribonucleic acid-based therapy for Myocardial Infarction: LncRNA DGCR5  inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 17/January/2019, 12.04 am
Ribonucleic acid-based therapy for Myocardial Infarction: LncRNA DGCR5  inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 17/January/2019, 12.04 am 960 720 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of the journal Nature,  by Prof Dimmler,…

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The erectile dysfunction drug sildenafil may protect against Myocardial Infarction: Sildenafil (brand name: viagra), a PDE5 inhibitor used in the treatment of erectile dysfunction and pulmonary hypertension, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 16/January/2019, 11.55 pm
The erectile dysfunction drug sildenafil may protect against Myocardial Infarction: Sildenafil (brand name: viagra), a PDE5 inhibitor used in the treatment of erectile dysfunction and pulmonary hypertension, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 16/January/2019, 11.55 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of the journal Nature,  by Prof Dimmler,…

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RNA-based therapy for aging-associated diseases and Lifespan extension: LncRNA HULC  inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging, via down-regulation of its target gene, 16/January/2019, 11.33 pm
RNA-based therapy for aging-associated diseases and Lifespan extension: LncRNA HULC  inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging, via down-regulation of its target gene, 16/January/2019, 11.33 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School…

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Molecular therapy for glaucoma: Trimetazidine (TMZ), the drug used in the treatment of angina pectoris,  increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 16/January/2018, 11.27 pm
Molecular therapy for glaucoma: Trimetazidine (TMZ), the drug used in the treatment of angina pectoris,  increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 16/January/2018, 11.27 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, USA; The Howard Hughes…

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Mechanistic insights into how Fasudil functions as a learning/memory/cognitive-enhancer:  Fasudil (brand name: hydroxyfasudil), a vasodilator used in the treatment of pulmonary hypertension, stroke and others, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 16/January/2019, 11.18 pm
Mechanistic insights into how Fasudil functions as a learning/memory/cognitive-enhancer:  Fasudil (brand name: hydroxyfasudil), a vasodilator used in the treatment of pulmonary hypertension, stroke and others, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 16/January/2019, 11.18 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of…

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