Ideas

September 18, 2018

Published by admin_auro at September 18, 2018

Categories

Anesthetic drug comes to the rescue of blood-stage Plasmodium infection: Procaine (PCA) (trade name: Novocain), a local anesthetic drug, decreases the expression of CTLA-4, PD-L1, and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clears blood-stage malaria, via up-regulation of its target gene, 18/September/2018, 7.35 am

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]

September 18, 2018

Published by admin_auro at September 18, 2018

Categories

Consuming a Probiotic once a day may insulate your heart against cardiac dysfunction: Probiotic Lactobacillus Plantarum-based adjunct therapy for cardiac hypertrophy and fibrosis: Probiotic Lactobacillus Plantarum decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 18/September/2018, 7.14 am

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]

September 18, 2018

Published by admin_auro at September 18, 2018

Categories

Ideas
Pain

A new mechanistic insight into a known heart failure medicine in Pain therapy: Dobutamine (brand name: dobutrex, inotrex), used in the treatment of congestive heart failure and cardiogenic shock, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 18/September/2018, 6.24 am

Introduction: What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for […]

September 16, 2018

Published by admin_auro at September 16, 2018

Categories

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Mibolerone (Trade name: Cheque drops and Matenon), an anabolic-androgenic steroid, increases the expression of tumor suppressors genes, such as HNF4α, CADM2, p53, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 17/September/2018, 12.04 am

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]