Little RNA can better your heart functioning: LncRNA Mirt2 -based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: LncRNA Mirt2 (Myocardial infarction-associated transcript 1 (Mirt1) increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 10/July/2019, 11.41 am

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April  2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20+), by Prof Tzahor E, D’Uva E, and others. […]

Natural product-based Lifespan extension therapy:  Polysaccharides, derived from Lycium barbarum L (LBL),  inhibit the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extend mammalian lifespan by regulating the expression of their target genes, 10/July/2019, 10.15 am

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 37.205 ),  by Prof. Dominic J. Withers, Dr. Selman C, […]

Little RNA may protect your heart from heart attack: Intracardiac injection of  LncRNA Mirt2 attenuates pathogenesis-associated with Myocardial infarction:  LncRNA Mirt2 decreases IRF3, GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leukocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up regulation of its target gene, 10/July/2019, 8.06 am

Introduction: What they say:  A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA shows that “IRF3 and type I interferons fuel a fatal response to myocardial infarction.” This study was published, in the 6 November 2017 […]

Solving a long standing puzzle as to how  ayurvedic medicine Ashwagantha attenuates cognitive dysfunction and prevents neurodegeneration: Mechanistic insights into how  Withaferin A, derived from Ashwagantha, attenuates cognitive dysfunction and neurodegeneration: Withaferin A, isolated from Ashwagantha,  decreases vascular cell adhesion molecule 1 (VCAM 1), inhibits microglia activity, increases hippocampal neural precursor activity, ameliorates cognition, & attenuates age-related neurodegeneration, through up regulation of its target genes, 8/July/2019, 10.47 am

Introduction: What they say A study from the Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA, VA Palo Alto Health Care System, Palo Alto, CA, USA, Palo Alto Veterans Institute for Research, Palo Alto, CA, USA, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA shows that “Aged blood […]

Consuming optimal amount of Flax seeds will make you live longer:  α-Linoleic acid, derived from Flax/Lin-seeds,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 8/July/2019, 6.06 am

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 37.205 ),  by Prof. Dominic J. Withers, Dr. Selman C, […]

Little RNA can save you from cardiac hypertrophy and fibrosis: Intracardiac injection of LncRNA Mirt2 protects against cardiac hypertrophy and fibrosis: Intracardiac  injection of LncRNA Mirt2 (Long non-coding RNA myocardial infarction associated transcript 2) decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function, via upregulation of its target gene, 6/July/2019, 11.14 pm

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, 80802, Munich, Germany; and Mount Sinai, Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA shows that […]