Ideas

June 24, 2018

Published by admin_auro at June 24, 2018

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Sitagliptin (trade name: Januvia), a DPP4 inhibitor, increases the expression of tumor suppressors genes, such as RECK, CADM1, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 24/June/2018, 8.19 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

June 24, 2018

Published by admin_auro at June 24, 2018

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Natural product-derived therapy for cardiac hypertrophy and fibrosis: A pharmaceutical mixture encompassing Alllicin, Diallyl disulfide & 4OMethylhonokiol (AD4OM) decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via up regulation of its target gene, 24/June/2017, 6.47 pm

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]

June 24, 2018

Published by admin_auro at June 24, 2018

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Why high glucose is not good for your heart: Mechanistic insights into how glucose-rich foods may accelerate cardiac ageing: High glucose augments DNA damage responses, attenuates telomerase expression, promotes telomere shortening, and attenuates cardiomyocyte survival after myocardial infarction, via down regulation of PNUTS, 24/June/2018, 5.52 pm

What they say: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March 2013 issue of of […]

June 24, 2018

Published by admin_auro at June 24, 2018

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BCG vaccine-based therapy for autoimmune diabetes (TIDM): BCG vaccine increases the expression of PD-L1, augments Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 24/June/2018, 5.20 pm

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]