Ideas

June 23, 2018

Published by admin_auro at June 23, 2018

Categories

Anti-hypertensive drug as an anti-hyperglycemic drug: Telmisartan (brand name: micardis), an angiotensin II receptor antagonist, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM, via up-regulation of its target gene., 23/June/2017, 6.40 pm

Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” This study was published, in the June […]

June 23, 2018

Published by admin_auro at June 23, 2018

Categories

Carbon monoxide-based therapy for regenerative muscle atrophy: COR-M2(Carbon monoxide (CO)- releasing molecule-2) increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 23/June/2018, 6.23 pm

Introduction: What they say A study from the Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai 200444, China shows that “miR-29b contributes […]

June 23, 2018

Published by admin_auro at June 23, 2018

Categories

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Sitagliptin (trade name: Januvia), a DPP4 inhibitor, increases the expression of tumor suppressors genes, such as PDCD4, PTEN, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 23/June/2018, 7.43 am

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

June 23, 2018

Published by admin_auro at June 23, 2018

Categories

Unearthing an unknown function of a known drug: Natural product-based combinatorial therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing Telmisartan(angiotensin II receptor antagonist), Epicatechin and Matrine (TEM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 23/June/2018, 7.33 am

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for […]