Ideas – Page 298

June 19, 2018

Published by admin_auro at June 19, 2018

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Sitagliptin (trade name: Januvia), a DPP4 inhibitor, increases the expression of tumor suppressors genes, such as TIMP3, CCM3/KRIT1, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 19/June/2017, 10.45 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

June 19, 2018

Published by admin_auro at June 19, 2018

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Lifespan- and healthspan-extension therapy: Shikonin, isolated from zicao/purple groomwell, may increase life span via up-regulation of its target gene BubR1 and others, 19/June/2018, 10.42 pm

What they say: Introduction: A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]

June 19, 2018

Published by admin_auro at June 19, 2018

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Natural product-derived therapy for cardiac hypertrophy and fibrosis: A pharmaceutical mixture encompassing Sulforaphane, Myricitrin and Aspalathin (SMA) decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via up regulation of its target gene, 19/June/2017, 10.36 pm

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]

June 19, 2018

Published by admin_auro at June 19, 2018

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Ideas
NAFLD

Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Cluster of differentiation (CD-30) promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via down regulation of its target gene, 19/June/2018, 10.30

Significance of the study: Given that: (1) 15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to […]