Ideas

December 23, 2017

Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy in Glioblastoma: A therapeutic mix encompassing Pravastatin, Herbimycin, Temozolomide, Zebularine, Salinomycin, and Clomipiramine (PHTZSC) inhibits oncoproteins EGFR, and Bcl-xl expression, increases tumor suppressor p53 expression, inhibits glioblastoma proliferation, increases interferon-IFNγ signalling, increase antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 24/December/2017, 12.42 am

Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy in Glioblastoma: A therapeutic mix encompassing Pravastatin, Herbimycin, Temozolomide, Zebularine, Salinomycin, and Clomipiramine (PHTZSC) inhibits oncoproteins EGFR, and Bcl-xl expression, increases tumor suppressor p53 expression, inhibits glioblastoma proliferation, increases interferon-IFNγ signalling, increase antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 24/December/2017, 12.42 am https://genomediscovery.org/wp-content/uploads/2017/12/PHTZSC-inhibits-the-expression-of-EGFR-and-Bcl2-xl-increases-p53-protein-levels-inhibits-a-number-of-immune-evasion-molecules-and-thereby-inhibits-GBM-progression.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2017/12/PHTZSC-inhibits-the-expression-of-EGFR-and-Bcl2-xl-increases-p53-protein-levels-inhibits-a-number-of-immune-evasion-molecules-and-thereby-inhibits-GBM-progression.jpg December 23, 2017 December 23, 2017

Introduction:What they say: A recent study from Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, David Geffen UCLA…

December 23, 2017

Natural product-derived therapy for enhancing anti-cancer immunity: Nimbolide, isolated from Neem (Azadirachta Indica), decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 24/December/2017, 12.35 am

Natural product-derived therapy for enhancing anti-cancer immunity: Nimbolide, isolated from Neem (Azadirachta Indica), decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 24/December/2017, 12.35 am https://genomediscovery.org/wp-content/uploads/2017/12/Nimbolide-increases-Cytotoxic-T-cell-and-B-cell-activity-enhances-anti-tumor-immunity-and-efficacy-through-down-regulation-of-LATS1-and-LATS2.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2017/12/Nimbolide-increases-Cytotoxic-T-cell-and-B-cell-activity-enhances-anti-tumor-immunity-and-efficacy-through-down-regulation-of-LATS1-and-LATS2.jpg December 23, 2017 December 23, 2017

Introduction: What they say: A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2…

December 22, 2017

Activation of the PD-1 pathway for Pain therapy: Lycopene (LYC), isolated from Gac, Guava, Tomatoes, and among others, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 23/December/2017, 2.24 am

Activation of the PD-1 pathway for Pain therapy: Lycopene (LYC), isolated from Gac, Guava, Tomatoes, and among others, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 23/December/2017, 2.24 am https://genomediscovery.org/wp-content/uploads/2017/12/Lycopene-may-protect-against-acute-and-chronic-pain-through-up-regulation-of-PD-L1.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2017/12/Lycopene-may-protect-against-acute-and-chronic-pain-through-up-regulation-of-PD-L1.jpg December 22, 2017 December 22, 2017

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

December 22, 2017

Natural product-derived therapy for improving cardiac contractility and attenuating pathogenesis associated with Myocardial infarction: A pharmaceutical mixture encompassing Withaferin A, Hesperidin and Isoorientin (WAHI) decreases GRK2 (G Protein-Coupled Receptor Kinase 2) and GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, increases cardiac contractility, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, promotes heart healing and inhibits glucose intolerance, via up regulation of its target gene, 23/December/2017, 2.13 am

Natural product-derived therapy for improving cardiac contractility and attenuating pathogenesis associated with Myocardial infarction: A pharmaceutical mixture encompassing Withaferin A, Hesperidin and Isoorientin (WAHI) decreases GRK2 (G Protein-Coupled Receptor Kinase 2) and GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, increases cardiac contractility, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, promotes heart healing and inhibits glucose intolerance, via up regulation of its target gene, 23/December/2017, 2.13 am https://genomediscovery.org/wp-content/uploads/2017/12/WAHI-may-enhance-cardiac-contractility-and-attenuate-pathogenesis-associated-with-myocardial-infarction-through-down-regulation-of-GRK2-and-GM-CSF.jpg2_.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2017/12/WAHI-may-enhance-cardiac-contractility-and-attenuate-pathogenesis-associated-with-myocardial-infarction-through-down-regulation-of-GRK2-and-GM-CSF.jpg2_.jpg December 22, 2017 December 22, 2017

Introduction: What they say: A recent study, from Department of Medicine, Division of Cardiology, Dept of Cell Biology, and Department of Molecular Genetics, Duke University Medical Center, Durham, North Carolina,…

December 22, 2017

Natural product-based therapy for Deafness: A therapeutic mix encompassing Lycopene(LYC), Cholecalciferol, and DIM (LYCCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via up regulation of its target genes, 23/December/2017, 1.58 am

Natural product-based therapy for Deafness: A therapeutic mix encompassing Lycopene(LYC), Cholecalciferol, and DIM (LYCCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via up regulation of its target genes, 23/December/2017, 1.58 am https://genomediscovery.org/wp-content/uploads/2017/12/Lycopene-may-protect-against-hearing-loss-through-induction-of-ATG5.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2017/12/Lycopene-may-protect-against-hearing-loss-through-induction-of-ATG5.jpg December 22, 2017 December 22, 2017

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Deafness: A therapeutic mix encompassing Lycopene(LYC), Cholecalciferol, and DIM (LYCCAD) increases the expression of ATG5 (Autophagy-related 5),…

December 22, 2017

Natural product therapy for body weight control, energy homeostasis and TIIDM: A therapeutic mix (PMSFN) encompassing Pyridoxamine (PM) and Sulforaphane (SFN) decreases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 23/December/2017, 1.51 am

Natural product therapy for body weight control, energy homeostasis and TIIDM: A therapeutic mix (PMSFN) encompassing Pyridoxamine (PM) and Sulforaphane (SFN) decreases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 23/December/2017, 1.51 am https://genomediscovery.org/wp-content/uploads/2017/12/A-pharmaceutical-mixture-PMSFN-promotes-insulin-sensitivity-and-weight-loss-through-regulation-of-CADMI-and-others.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2017/12/A-pharmaceutical-mixture-PMSFN-promotes-insulin-sensitivity-and-weight-loss-through-regulation-of-CADMI-and-others.jpg December 22, 2017 December 22, 2017

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule1.”…

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