Ideas

Combinatorial therapy for improving cardiac contractility and attenuating pathogenesis associated with Myocardial infarction: A pharmaceutical mixture encompassing Matrine, Epicatechin, 14, 15, Epoxyeicosatrienoicacids (14, 15 EETs) (MEEET)  decreases GRK2 (G Protein-Coupled Receptor Kinase 2) and GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, increases cardiac contractility, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, promotes heart healing and inhibits glucose intolerance, via up regulation of its target gene, 25/December/2017, 1.37 am
Combinatorial therapy for improving cardiac contractility and attenuating pathogenesis associated with Myocardial infarction: A pharmaceutical mixture encompassing Matrine, Epicatechin, 14, 15, Epoxyeicosatrienoicacids (14, 15 EETs) (MEEET)  decreases GRK2 (G Protein-Coupled Receptor Kinase 2) and GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, increases cardiac contractility, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, promotes heart healing and inhibits glucose intolerance, via up regulation of its target gene, 25/December/2017, 1.37 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study, from Department of Medicine, Division of Cardiology, Dept of Cell Biology, and Department of Molecular Genetics, Duke University Medical Center, Durham, North Carolina,…

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Natural product therapy for Non-alcoholic fatty liver disease (NAFLD): Rosmarinic acid, isolated from Rosemary officinalis, and Perilla frutescens,  promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 24/December/2017, 11.51 pm
Natural product therapy for Non-alcoholic fatty liver disease (NAFLD): Rosmarinic acid, isolated from Rosemary officinalis, and Perilla frutescens,  promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 24/December/2017, 11.51 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in…

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Molecular therapy for Deafness: A therapeutic mix encompassing Moxonidine, Cholecalciferol, Ajoene and DIM (MOCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 24/December/2017, 11.43 pm
Molecular therapy for Deafness: A therapeutic mix encompassing Moxonidine, Cholecalciferol, Ajoene and DIM (MOCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 24/December/2017, 11.43 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Molecular therapy for Deafness: A therapeutic mix encompassing Moxonidine, Cholecalciferol, Ajoene and DIM (MOCAD)  increases the expression of ATG5 (Autophagy-related 5),…

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Molecular therapy for Diabetic retinopathy: Dimethyl Fumerate (DMF) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 24/December/2017, 1.10 am
Molecular therapy for Diabetic retinopathy: Dimethyl Fumerate (DMF) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 24/December/2017, 1.10 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for Cardiovascular Research (DZHK) partner…

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Molecular therapy for TIIDM and obesity-associated metabolic deficits: A pharmaceutical mixture (PMSFN) encompassing Pyridoxamine (PM) and Sulforaphane (SFN)  increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 24/December/2017, 1.01 pm
Molecular therapy for TIIDM and obesity-associated metabolic deficits: A pharmaceutical mixture (PMSFN) encompassing Pyridoxamine (PM) and Sulforaphane (SFN)  increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 24/December/2017, 1.01 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent suppression of appetite…

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Molecular therapy for Cardiomyopathy: Lycopene (LYC), isolated from Gac, Guava, and Tomatoes, among others, decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 24/December/2017,  12.51 am
Molecular therapy for Cardiomyopathy: Lycopene (LYC), isolated from Gac, Guava, and Tomatoes, among others, decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 24/December/2017,  12.51 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say   A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.” This…

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