Ideas

Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of oncomiR MiR-17-92, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 20/January/2016, 10.17 pm
Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of oncomiR MiR-17-92, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 20/January/2016, 10.17 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may inhibit the expression of oncomiR MiR-17-92. [easy_payment currency=”USD”] Thereby, it may…

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Cardiac rejuvenation therapy: β-Cellulin (BTC), a ligand for the EGF receptor, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 20/January/2017, 10.00 pm
Cardiac rejuvenation therapy: β-Cellulin (BTC), a ligand for the EGF receptor, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 20/January/2017, 10.00 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure…

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Natural product-derived PD-1 pathway blockade for Human cancer therapy: Alantolactone, present in Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 19/January/2017, 11.58 pm
Natural product-derived PD-1 pathway blockade for Human cancer therapy: Alantolactone, present in Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 19/January/2017, 11.58 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Ascochlorin (ASC), an isoprenoid antibiotic, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 19/January/2017, 11.36 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Ascochlorin (ASC), an isoprenoid antibiotic, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 19/January/2017, 11.36 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Natural product-derived therapy for glucose homeostasis and TIIDM: Naringenin, a flavone found in Grapefruits, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 19/January/2017, 11.23 pm
Natural product-derived therapy for glucose homeostasis and TIIDM: Naringenin, a flavone found in Grapefruits, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 19/January/2017, 11.23 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that…

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Anti-metastasis therapy for human tumors: Ascochlorin, an isoprenoid antibiotic isolated from an incomplete fungus Ascochyta viciae, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 19/January/2017, 6.53 am
Anti-metastasis therapy for human tumors: Ascochlorin, an isoprenoid antibiotic isolated from an incomplete fungus Ascochyta viciae, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 19/January/2017, 6.53 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102,…

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