Ideas

August 10, 2017

Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Fisetin and Vitamin-D dissolved in Hydrogen-rich water activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 10/August/2017, 11.42 pm

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]
August 10, 2017

Natural product-derived therapy for therapy-resistant cancers: A therapeutic mix encompassing Phenethyl isothiocyanate (PEITC), β-Cryptoxanthine (BCX) and Berberine (BBR) inhibits the expression of phospholipid glutathione peroxidase (GPX4), inhibits GPX4 signaling network and lipid peroxidase pathway, suppresses EMT protein ZEB1, increases sensitivity to anticancer therapy and prolongs survival via up regulation of its target gene, 10/August/2017, 11.32 pm

Introduction: What they say: A study from Broad Institute, Cambridge, Massachusetts, USA, Howard Hughes Medical Institute, Chevy Chase, Maryland and Department of Chemistry and Chemical Biology, […]
August 10, 2017

 Natural product-derived therapy for prostate cancer: Myrtenal, one of the main components of Mint, Peppers and among others, inhibits the expression of mTORC1 and its downstream target AMD1, dismantles mTORC1-AMD1 signaling network, decreases polyamine levels, and inhibits prostate cancer progression via up regualtion of its target gene, 10/August/2017, 11.23 pm

Introduction: What they say: A study from CIC bioGUNE (Center for Cooperative Research in Biosciences), Bizkaia Technology Park, 801 Building, 48160 Derio, Spain shows that “mTORC1-dependent AMD1 regulation sustains polyamine […]
August 10, 2017

Antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Auranofin, a drug used in the treatment of Rheumatoid arthritis,  increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 10/August/2017, 10.45 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]
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