Ideas

Natural product-derived therapy for enhancing anti-cancer immunity: Indole-3-carbinol (I3C), found in Broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale among others, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 17/January/2017, 11.58 pm
Natural product-derived therapy for enhancing anti-cancer immunity: Indole-3-carbinol (I3C), found in Broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale among others, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 17/January/2017, 11.58 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2…

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Small molecule-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Unacylated ghrelin (UnAG) inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 17/January/2017, 11.35 pm
Small molecule-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Unacylated ghrelin (UnAG) inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 17/January/2017, 11.35 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows…

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Natural product-derived PD-1 pathway blockade for Human cancer therapy: Baicalein, isolated from Scutellaria Baicalensis/Lateriflora and Oroxylum indicum among others, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 17/January/2017, 11.17 pm
Natural product-derived PD-1 pathway blockade for Human cancer therapy: Baicalein, isolated from Scutellaria Baicalensis/Lateriflora and Oroxylum indicum among others, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 17/January/2017, 11.17 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Natural product-based Life-extension therapy: Aloe vera inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 17/January/2017, 10.51 pm
Natural product-based Life-extension therapy: Aloe vera inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 17/January/2017, 10.51 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Natural product-based Immune enhancement therapy: Cucrumin, one of the main components of turmeric, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 17/January/2017, 10.27 pm
Natural product-based Immune enhancement therapy: Cucrumin, one of the main components of turmeric, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 17/January/2017, 10.27 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate…

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Anticancer therapy targeting the cancer stem cells: MiRNA-9600 increases the expression of tumor suppressor PTEN, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 17/January/2016, 10.09 pm
Anticancer therapy targeting the cancer stem cells: MiRNA-9600 increases the expression of tumor suppressor PTEN, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 17/January/2016, 10.09 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may increase the expression of tumor suppressor PTEN. [easy_payment currency=”USD”] Thereby, it…

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