Ideas

Natural product-derived Life-extension therapy: Withaferin A, a lactone isolated from herb Withania Somnifera/Ashwagandha and Acnistus arborescens, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 11/January/2017, 9.18 am
Natural product-derived Life-extension therapy: Withaferin A, a lactone isolated from herb Withania Somnifera/Ashwagandha and Acnistus arborescens, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 11/January/2017, 9.18 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 11/January/2017, 8.48 pm
Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 11/January/2017, 8.48 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Research findings to Therapeutic opportunity:  The study presented here suggests that Calycosin, by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine dehydrogenase (DPYD); (ii) increase 5-FU accumulation…

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Natural product-derived therapy for Metastatic human tumors: Linalool, one of the main components of Coriander seeds and Lamiaceae among others, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 11/January/2017, 10.38 pm
Natural product-derived therapy for Metastatic human tumors: Linalool, one of the main components of Coriander seeds and Lamiaceae among others, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 11/January/2017, 10.38 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102,…

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Natural product therapy for glucose homeostasis and TIIDM: Ajoene, derived from Garlic, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensisitity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 10/January/2017, 11.38 pm
Natural product therapy for glucose homeostasis and TIIDM: Ajoene, derived from Garlic, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensisitity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 10/January/2017, 11.38 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that…

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Natural product-derived therapy for Metastatic human tumors: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes of glycolysis, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 10/January/2017, 11.20 pm
Natural product-derived therapy for Metastatic human tumors: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes of glycolysis, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 10/January/2017, 11.20 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102,…

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Cardiac rejuvenation therapy: Transcriptional co-activator with PDZ-binding motif (TAZ) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 10/January/2017, 9.43 pm
Cardiac rejuvenation therapy: Transcriptional co-activator with PDZ-binding motif (TAZ) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 10/January/2017, 9.43 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure…

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