Ideas

Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Guttiferone K (GUTK), found in Garcinia cambogia, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 13/January/2017, 10.31 pm
Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Guttiferone K (GUTK), found in Garcinia cambogia, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 13/January/2017, 10.31 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Research findings to Therapeutic opportunity:  The study presented here suggests that Guttiferone K (GUTK), by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine dehydrogenase (DPYD);…

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Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor Interleukin-1β (IL-1β), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 13/January/2016, 10.26 pm
Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor Interleukin-1β (IL-1β), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 13/January/2016, 10.26 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of Interleukin-1β (IL-1β). [easy_payment currency=”USD”] Thereby, it may…

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Natural product-derived Life-extension therapy: Sauchinone, an antioxidant lignan found in Saururus chinensis, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/January/2017, 10.19 am
Natural product-derived Life-extension therapy: Sauchinone, an antioxidant lignan found in Saururus chinensis, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/January/2017, 10.19 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Immune enhancement therapy: Estradiol (E2) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 13/January/2017, 10.10 pm
Immune enhancement therapy: Estradiol (E2) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 13/January/2017, 10.10 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate…

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Anti-telomerase cancer therapy: Javamide-II suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 13/January/2017, 6.40 am
Anti-telomerase cancer therapy: Javamide-II suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 13/January/2017, 6.40 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1…

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Natural product-derived Immune enhancement therapy: Areca Nut extract/Arecoline increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 12/January/2017, 10.07 pm
Natural product-derived Immune enhancement therapy: Areca Nut extract/Arecoline increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 12/January/2017, 10.07 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate…

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