Ideas

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Sauchinone, an antioxidant lignan found in Saururus chinensis, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 12/December/2016, 9.35 am
Natural product-derived PD-1 pathway blockade for Human cancer therapy: Sauchinone, an antioxidant lignan found in Saururus chinensis, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 12/December/2016, 9.35 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Natural product-derived therapy for Metastatic human tumors: Schisandrin B, one of the main components of Schisandra chinensis, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 12/January/2017, 7.05 am
Natural product-derived therapy for Metastatic human tumors: Schisandrin B, one of the main components of Schisandra chinensis, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 12/January/2017, 7.05 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102,…

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Natural product-derived Life-extension therapy: Cucurbitacin I, found in Citrullus colocynthis, and Cucurbita andreana among others, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 12/January/2017, 6.54 am
Natural product-derived Life-extension therapy: Cucurbitacin I, found in Citrullus colocynthis, and Cucurbita andreana among others, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 12/January/2017, 6.54 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Natural product-derived Immune enhancement therapy: Kaemphferol increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 11/January/2017, 10.45 pm
Natural product-derived Immune enhancement therapy: Kaemphferol increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 11/January/2017, 10.45 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate…

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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Punica granatum extract inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 11/January/2017, 10.37 pm
Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Punica granatum extract inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 11/January/2017, 10.37 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows…

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Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor protein Suppressor Of Cytokine Signaling 1 (SOCS1), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 11/January/2016, 10.28 pm
Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor protein Suppressor Of Cytokine Signaling 1 (SOCS1), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 11/January/2016, 10.28 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor Suppressor Of Cytokine Signaling 1…

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