Ideas

August 16, 2017

Natural product-derived therapy for gynecologic cancers: Shikonin, one of the main components of herb Zicao, inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 17/August/2017, 12.57 am

Introduction: What they say: A study from Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA shows that “ARID1A-mutated ovarian cancers depend on […]
August 16, 2017

Molecular therapy for Metastatic cancers: Ivermectin, the anthelmintic drug, increases the expression of metastasis suppressors TAp63 and TPM1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 17/August/2017, 12.51 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
August 16, 2017

Molecular-therapy for Regenerating the lost pancreatic β-cells in Diabetic patients:  N-Acetyl Cysteine (NAC) increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of  its target gene Lin28, 17/August/2017, 12.38 am

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
August 16, 2017

Natural product-derived therapy for inflammation and arthritis: Kaempferol, isolated from Greater cappers, Kale and among others, increases IL-9 levels, increases proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up regualtion of its target genes, 16/August/2017, 11.23 pm

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that […]
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