Ideas

Natural product-derived therapy for enhancing anti-cancer immunity: Withaferin A, one of the main components of Acnistus arborescens, and Ashwagantha among others, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 5/January/2017, 11.42 am
Natural product-derived therapy for enhancing anti-cancer immunity: Withaferin A, one of the main components of Acnistus arborescens, and Ashwagantha among others, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 5/January/2017, 11.42 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2…

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Vitamin-based therapy for triple-negative breast tumors: 1α,25-dihydroxyvitamin D(3)/Calcitriol increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 4/January/2017, 10.15 pm
Vitamin-based therapy for triple-negative breast tumors: 1α,25-dihydroxyvitamin D(3)/Calcitriol increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 4/January/2017, 10.15 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as…

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Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 4/January/2017, 10.01 pm
Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 4/January/2017, 10.01 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Research findings to Therapeutic opportunity:  The study presented here suggests that Bergapten (5-methoxypsoralen), by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine dehydrogenase (DPYD); (ii) increase 5-FU…

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Life-extension therapy: Glimepride (Trade name: Amaryl), a sulphonylurea antidiabetic drug, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 4/January/2017, 5.49 pm
Life-extension therapy: Glimepride (Trade name: Amaryl), a sulphonylurea antidiabetic drug, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 4/January/2017, 5.49 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Vitamin-based Cardiac rejuvenation therapy: Ascorbic acid suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 4/January/2017, 3.20 pm
Vitamin-based Cardiac rejuvenation therapy: Ascorbic acid suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 4/January/2017, 3.20 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure…

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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Matrine, isolated from Sophora flavescens, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 4/January/2017, 3.06 pm
Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Matrine, isolated from Sophora flavescens, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 4/January/2017, 3.06 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows…

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