Ideas

Vitamin therapy for overcoming chemoresistance in Human cancers: δ-tocotrienol (a form of Vitamin-E) increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 4/January/2016, 12.15 pm
Vitamin therapy for overcoming chemoresistance in Human cancers: δ-tocotrienol (a form of Vitamin-E) increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 4/January/2016, 12.15 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Figure 1. Annato bixaorellana. Delta-tocotrienol is enriched in Annato bixaorellana. From Research findings to Therapeutic opportunity:  The study presented here suggests that δ-tocotrienol, by increasing the expression of its target genes, it…

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Natural product-derived therapy for H. pylori–induced Gastric cancer: Amla extract inhibits WNT-SOX9 pathway, decreases oncogenic β-catenin levels, suppresses H. pylori-induced gastric cancer proliferation, inhibits acquisition of tumor-initiating stem-cell properties and decreases chemoresistance via up regulation of its target gene, 4/January/2017, 5.48 am
Natural product-derived therapy for H. pylori–induced Gastric cancer: Amla extract inhibits WNT-SOX9 pathway, decreases oncogenic β-catenin levels, suppresses H. pylori-induced gastric cancer proliferation, inhibits acquisition of tumor-initiating stem-cell properties and decreases chemoresistance via up regulation of its target gene, 4/January/2017, 5.48 am 150 150 Dr Boomi's Genom-2-Discovery Center

From Research findings to Therapeutic opportunity:  The study presented here suggests that Amla extract, by increasing the expression of its target genes, it may: (i) inhibit WNT-SOX9 oncogenic pathway; (ii) decrease oncogenic β-catenin protein levels;…

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Anti-telomerase cancer therapy: MiR-601 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 3/January/2017, 7.25 pm
Anti-telomerase cancer therapy: MiR-601 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 3/January/2017, 7.25 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1…

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Small molecule-based PD-1 pathway blockade for Human cancer therapy: Linagliptin (brand name: BI-1356/Tradjenta), an inhibitor of dipeptidylpeptidase-4 (DPP-4), increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 3/January/2017, 5.12 pm
Small molecule-based PD-1 pathway blockade for Human cancer therapy: Linagliptin (brand name: BI-1356/Tradjenta), an inhibitor of dipeptidylpeptidase-4 (DPP-4), increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 3/January/2017, 5.12 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Cardiac rejuvenation therapy: AML-3 (Cbfa1/Runx2) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 3/January/2017, 2.09 pm
Cardiac rejuvenation therapy: AML-3 (Cbfa1/Runx2) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 3/January/2017, 2.09 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure…

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Life-extension therapy: Pioglitazone, an antidiabetic medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/January/2017, 1.41 pm
Life-extension therapy: Pioglitazone, an antidiabetic medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/January/2017, 1.41 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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