Ideas

Natural product-derived therapy for H. pylori–induced Gastric cancer: Curcumin, one of the main components of Turmeric, inhibits WNT-SOX9 pathway, decreases oncogenic β-catenin levels, suppresses H. pylori-induced gastric cancer proliferation, inhibits acquisition of tumor-initiating stem-cell properties and decreases chemoresistance via up regulation of its target gene, 3/January/2017, 1.24 pm
Natural product-derived therapy for H. pylori–induced Gastric cancer: Curcumin, one of the main components of Turmeric, inhibits WNT-SOX9 pathway, decreases oncogenic β-catenin levels, suppresses H. pylori-induced gastric cancer proliferation, inhibits acquisition of tumor-initiating stem-cell properties and decreases chemoresistance via up regulation of its target gene, 3/January/2017, 1.24 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Research findings to Therapeutic opportunity:  The study presented here suggests that Curcumin, by increasing the expression of its target genes, it may: (i) inhibit WNT-SOX9 oncogenic pathway; (ii) decrease oncogenic β-catenin protein levels; (iii)…

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Natural product-derived Immune enhancement therapy: Oleanolic acid, found in Syzygium S. or Jawa apple and among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 3/January/2017, 1.03 pm
Natural product-derived Immune enhancement therapy: Oleanolic acid, found in Syzygium S. or Jawa apple and among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 3/January/2017, 1.03 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate…

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Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Puerarin, isolated from Cucurbita texana, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 3/January/2017, 11.53 am
Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Puerarin, isolated from Cucurbita texana, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 3/January/2017, 11.53 am 150 150 Dr Boomi's Genom-2-Discovery Center

What is known? I have published earlier that Puerarin may suppress the expression of Tripeptidyl Peptidase 1 (TPP1) and Telomerase and inhibit cancer progression.  From Research findings to Therapeutic opportunity:  The…

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Molecular therapy for Bone disorders: ARIH2 nhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 2/January/2017, 11.00 pm
Molecular therapy for Bone disorders: ARIH2 nhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 2/January/2017, 11.00 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis…

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Small molecule-based PD-1 pathway blockade for Human cancer therapy: HOXA10 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 2/January/2017, 10.53 pm
Small molecule-based PD-1 pathway blockade for Human cancer therapy: HOXA10 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 2/January/2017, 10.53 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on…

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Molecular therapy for Myocardial Infarction: Sitagliptin, a Dipeptidyl peptidase-4 (DPP-4) inhibitor and an anti-hyperglycemic drug, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 2/January/2017, 10.35 pm
Molecular therapy for Myocardial Infarction: Sitagliptin, a Dipeptidyl peptidase-4 (DPP-4) inhibitor and an anti-hyperglycemic drug, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 2/January/2017, 10.35 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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