Ideas – Page 556

September 9, 2017

Published by admin_auro at September 9, 2017

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Cancer
Ideas

Molecular therapy for Metastatic cancers: Geniposide, isolated from Gardenia, increases the expression of tumor suppressors TIMP3 and CCM3/KRIT1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 10/September/2017, 12.38 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]

September 9, 2017

Published by admin_auro at September 9, 2017

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Ideas
NAFLD

Steroid-based therapy for Non-alcoholic fatty liver disease (NAFLD): Prostaglandin(PGE2) promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 9/September/2017, 12/25 am

Significance of the study: Given that: (1) 15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while only 6-25% of Asian populations suffer from it; […]

September 9, 2017

Published by admin_auro at September 9, 2017

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Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Withaferin A, Astaxanthin, 5-aza-2′-deoxycytidine, Cirivastatin, PEITC, Tubastatin, & Celastrol (WAAACPTC) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 10/September/2017,12.14 am

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands has identified […]

September 9, 2017

Published by admin_auro at September 9, 2017

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Natural product-derived therapy for inflammation and arthritis: A pharmaceutical mixture encompassing Icariin and Tetrandrine increases IL-9 levels, increases proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up regualtion of its target genes, 10/September/2017, 12.09 am

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that […]