Ideas

Molecular therapy for Myocardial Infarction: NMI (N-myc interactor) inhibit DNA damage responses, increase telomerase expression, inhibit telomere shortening, and promote cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 22/December/2016, 11.03 pm
Molecular therapy for Myocardial Infarction: NMI (N-myc interactor) inhibit DNA damage responses, increase telomerase expression, inhibit telomere shortening, and promote cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 22/December/2016, 11.03 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

read more

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Garlic increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 22/December/2016, 10.53 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Garlic increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 22/December/2016, 10.53 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

read more

Natural product-derived therapy for enhancing anti-cancer immunity: Cardamonin decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 22/December/2016, 10.33 pm
Natural product-derived therapy for enhancing anti-cancer immunity: Cardamonin decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 22/December/2016, 10.33 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2…

read more

Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Withaferin A, a lactone isolated from herb Withania Somnifera/Ashwagandha and Acnistus arborescens, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 22/December/2016, 8.29 pm
Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Withaferin A, a lactone isolated from herb Withania Somnifera/Ashwagandha and Acnistus arborescens, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 22/December/2016, 8.29 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows…

read more

Small molecule-based PD-1 pathway blockade for Human cancer therapy: NQO1 (NAD(P)H dehydrogenase [quinone] ) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 21/December/2016, 11.30 pm
Small molecule-based PD-1 pathway blockade for Human cancer therapy: NQO1 (NAD(P)H dehydrogenase [quinone] ) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 21/December/2016, 11.30 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on…

read more

Molecular therapy for Myocardial Infarction: Lithium, the widely used drug in the treatment of depressive/bipolar disorders, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 21/December/2016, 11.07 pm
Molecular therapy for Myocardial Infarction: Lithium, the widely used drug in the treatment of depressive/bipolar disorders, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 21/December/2016, 11.07 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

read more
Start Typing