Ideas

Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: α-Lipoic acid, found in Brussels, broccoli, rice bran and among others, decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 24/December/2016, 11.14 pm
Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: α-Lipoic acid, found in Brussels, broccoli, rice bran and among others, decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 24/December/2016, 11.14 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published…

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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 24/December/2016, 10.45 pm
Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 24/December/2016, 10.45 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Cancer Suppressor BMP4 increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 24/December/2016, 9.36 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Cancer Suppressor BMP4 increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 24/December/2016, 9.36 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Natural product-derived therapy for enhancing anti-cancer immunity: Berberine, found in Berberis, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 23/December/2016, 10.16 pm
Natural product-derived therapy for enhancing anti-cancer immunity: Berberine, found in Berberis, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 23/December/2016, 10.16 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2…

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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Kukoamine A, a spermine alkaloid derived from Cortex lycii radicis, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 23/December/2016, 9.46 pm
Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Kukoamine A, a spermine alkaloid derived from Cortex lycii radicis, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 23/December/2016, 9.46 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows…

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Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: Eriocitrin, a flavonoid found in Lemons, decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 23/December/2016, 1.56 pm
Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: Eriocitrin, a flavonoid found in Lemons, decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 23/December/2016, 1.56 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published…

read more
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