Ideas

Natural product-derived therapy for enhancing anti-cancer immunity: Hesperidin, found abundantly in Citrus fruits, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 20/December/2016, 6.27 pm
Natural product-derived therapy for enhancing anti-cancer immunity: Hesperidin, found abundantly in Citrus fruits, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 20/December/2016, 6.27 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2…

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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Rhamnetin, an O-methylated flavonoid isolated from herb Cloves, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 20/December/2016, 3.00 pm
Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Rhamnetin, an O-methylated flavonoid isolated from herb Cloves, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 20/December/2016, 3.00 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: American ginseng increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 20/December/2016, 11.46 am
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: American ginseng increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 20/December/2016, 11.46 am 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Immune enhancement therapy: HIF-2α increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 19/December/2016, 10.14 pm
Immune enhancement therapy: HIF-2α increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 19/December/2016, 10.14 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angel” in mutant p53-expressing human tumors: MiR-329 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 19/December/2016, 10.04 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angel” in mutant p53-expressing human tumors: MiR-329 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 19/December/2016, 10.04 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Molecular therapy for triple-negative breast tumors: PDLIM2 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 19/December/2016, 9.56 pm
Molecular therapy for triple-negative breast tumors: PDLIM2 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 19/December/2016, 9.56 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as…

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