Ideas

September 1, 2017

Published by admin_auro at September 1, 2017

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Molecular therapy for TIIDM and obesity-associated metabolic deficits: Ruxolitinib, a drug used in the treatment of Myelofibrosis, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 1/September/2017, 11.28 pm

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that […]

September 1, 2017

Published by admin_auro at September 1, 2017

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Life-extension therapy: Long ncRNA MEG3 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span by regulating the expression of its target genes, 1/September/2017, 11.01 pm

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]

September 1, 2017

Published by admin_auro at September 1, 2017

Categories

Cancer
Ideas

Natural product-based PD-1 pathway blockade for Human cancer therapy: Lovastatin, a cholesterol lowering drug, decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 1/September, 2017, 10.54 pm

Introduction:What they say: A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase […]

August 31, 2017

Published by admin_auro at August 31, 2017

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Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Baicalein, DIM, and Cholecalciferol activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 1/September/2017, 1.46 am

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]