Ideas

Natural product-derived therapy for Human Leukemias: Grifolin, an antitumor natural product from mushroom Albatrellus confluens, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 13/December/2016, 11.01 pm
Natural product-derived therapy for Human Leukemias: Grifolin, an antitumor natural product from mushroom Albatrellus confluens, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 13/December/2016, 11.01 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to…

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Molecular therapy for Myocardial Infarction: Snail/SNAI1 (snail family zinc finger 1), a positive regulator of epithelial-mesenchymal transition, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 13/December/2016, 10.42 pm
Molecular therapy for Myocardial Infarction: Snail/SNAI1 (snail family zinc finger 1), a positive regulator of epithelial-mesenchymal transition, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 13/December/2016, 10.42 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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Anticancer therapy: MiRNA-9600 increases the expression of pro-apoptotic protein RECK, inhibits proliferation, and promote apoptosis of cancer cells via down regulation of its target gene, 13/December/2016, 10.26 pm
Anticancer therapy: MiRNA-9600 increases the expression of pro-apoptotic protein RECK, inhibits proliferation, and promote apoptosis of cancer cells via down regulation of its target gene, 13/December/2016, 10.26 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of pro-apoptotic protein  RECK. [easy_payment currency=”USD”] Thereby, it…

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Natural product-derived therapy for overcoming chemoresistance in Human cancers:Luteolin, a flavonoid found in Salvia tomentosa, Perilla, and thyme among others, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 13/December/2016, 10.08 pm
Natural product-derived therapy for overcoming chemoresistance in Human cancers:Luteolin, a flavonoid found in Salvia tomentosa, Perilla, and thyme among others, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 13/December/2016, 10.08 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Research findings to Therapeutic opportunity:  The study presented here suggests that Luteolin, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decreases BMI1 translocation; (iii)…

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Anti-telomerase cancer therapy: MiR-329 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 13/December/2016, 2.32 pm
Anti-telomerase cancer therapy: MiR-329 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 13/December/2016, 2.32 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1…

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Natural product-derived therapy for Human Leukemias: Naringenin, found in grapefruit, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 12/December/2016, 9.34 pm
Natural product-derived therapy for Human Leukemias: Naringenin, found in grapefruit, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 12/December/2016, 9.34 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to…

read more
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