Ideas

August 27, 2017

Published by admin_auro at August 27, 2017

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Cancer
Ideas

Natural product-derived therapy for Acute Myeloid Leukemia: A therapeutic mix encompassing Ivermectin and Curcumin decreases the expression of BCLAF1, promotes differentiation of acute myeloid leukemic cells, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and promotes regression of AML via up-regulation of its target gene, 28/August/2017, 12.23 am

Introduction: What they say: A study from the Institute of Genetics and Biophysics, CNR, Naples, Italy; and Department of Biochemistry, Biophysics and General Pathology, Second University […]

August 27, 2017

Published by admin_auro at August 27, 2017

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Natural product therapy for pulmonary arterial hypertension: Curcumin, isolated from Turmeric, inhibits the development of pulmonary arterial hypertension via down regulation of Notch3 and its target gene Hes-5, 28/August/2017, 12.14 am

What they say: A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number […]

August 27, 2017

Published by admin_auro at August 27, 2017

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Natural product-derived Combinatorial therapy targeting CMTM6/4-PD-L1 pathway enhances the efficacy of Cancer immunotherapy: A therapeutic mix encompassing Berberine , Nimbolide and N-Acetylcysteine (BNN) inhibits the expression of transmembrane protein CMTM6/CMTM4, increases interferon-IFNγ signalling, augments antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 27/August/2017, 3.48 pm

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan, CX Amsterdam, The Netherlands has identified CMTM6 and […]

August 27, 2017

Published by admin_auro at August 27, 2017

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Antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Ivermectin (Brand name: Heartguard/Mectizen/Stromectol), the antihelminthic drug, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 27/August/2017, 9. 14 am

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]