PreImplantation Factor (PIF)-based therapy for autoimmune diabetes (TIDM): Synthetic preimplantation factor (sPIF) increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 12/April/2019, 8.31 am