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January 2, 2017
Published by admin_auro at January 2, 2017
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Molecular therapy for Bone disorders: ARIH2 nhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 2/January/2017, 11.00 pm

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone […]
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January 2, 2017
Published by admin_auro at January 2, 2017
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Small molecule-based PD-1 pathway blockade for Human cancer therapy: HOXA10 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 2/January/2017, 10.53 pm

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]
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January 2, 2017
Published by admin_auro at January 2, 2017
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Molecular therapy for Myocardial Infarction: Sitagliptin, a Dipeptidyl peptidase-4 (DPP-4) inhibitor and an anti-hyperglycemic drug, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 2/January/2017, 10.35 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
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January 2, 2017
Published by admin_auro at January 2, 2017
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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Pioglitazone (trade name: Actos), an antihyperglycemic drug, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 2/January/2017, 8.26 am

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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