What they say:
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Estradiol functions as a longevity promoter: Estradiol, a female steroid hormone, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene
Research findings to Therapeutic opportunity:
Estradiol(E2), a steroid female sex hormone, has also been shown to aid in the treatment of a number of other gynecological conditions. This study suggests, for the first time, that Estradiol(E2), by increasing the expression of its target gene, it may suppress ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote (1) resistance to the bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
Figure 1. Mechanistic insight into how Estradiol(E2) may extend lifespan. Estradiol(E2) inhibits p70 S6 kinase expression and increases the expression of other longevity- promoting genes.
Figure 2. The chemical structure of Estradiol(E2). Estradiol(E2) functions as a longevity promoting agent through down-regulation of p70S6 kinase
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Thus, pharmacological formulations encompassing “Estradiol or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),“ may be used to extend the lifespan of an individual (fig. 2).
Given the mechanistic basis of how Estradiol may function as a longevity-promoting agent, obstetricians and gynecologists and general practitioners may consider: encouraging their needy patients(post-menopausal women) to take Estradiol or beginning a clinical trial.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How Estradiol decreases the expression of p70 S6 Kinase and promotes mammalian lifespan
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References:
Citation: Boominathan, L., Estradiol functions as a longevity promoter: Estradiol, a female steroid hormone, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 19/August/2017, 11.23 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
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