What they say:
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March 2013 issue of of the journal Nature, by Prof Dimmler, Boon, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Have copious amounts of natural sugar Rhamnose to stay protected against myocardial diseases: L- Rhamnose protects against and promotes functional recovery after Myocardial Infarction: L- Rhamnose (6-deoxy-L-Mannose) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of its target gene
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From Significance of the study to Public Health relevance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from 123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.
From Research Findings to Therapeutic Opportunity:
This study suggests, for the first time, a natural sugar Rhamnose (6-deoxy-L-Mannose)-based therapy for protection against myocardial infarction.
Rhamnose (6-deoxy-L-Mannose), by increasing the expression of its target genes, it may increase the expression of PNUTS (fig.1) . Thereby, it may: (1) inhibit DNA damage responses, (2) increase telomerase expression, (3) inhibit telomere shortening; (4) promote cardiomyocyte survival/regeneration; (5) decelerate aging; and (6) extend lifespan (fig 1).
Figure 1. Rhamnose (6-deoxy-L-Mannose) functions as a Cardioprotective agent. Mechanistic insights into how Rhamnose (6-deoxy-L-Mannose) induces the expression of PNUTS and telomerase to prevent myocardial infarction; and promote cardiac regeneration/survival
Figure 2. Rhamnose (6-deoxy-L-Mannose) functions as a cardioprotective agent through induction of cardiomyocyte survival protein PNUTS
Thus, by making cardiac patients to consume Rhamnose (6-deoxy-L-Mannose), one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests, for the first time, that Rhamnose (6-deoxy-L-Mannose) may be used to protect against myocardial infarction or improve cardiac function after myocardial infarction (fig. 2).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does Rhamnose (6-deoxy-L-Mannose) increase the expression of PNUTS/Telomerase?
Amount: $300#
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References:
Web:http://genomediscovery.org or http://newbioideas.com/
Citation: Boominathan, L., Have copious amounts of natural sugar Rhamnose to stay protected against myocardial diseases: L- Rhamnose protects against and promotes functional recovery after Myocardial Infarction: L- Rhamnose (6-deoxy-L-Mannose) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of its target gene, 12/May/2019, 6.30 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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