What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the journal “EMBO”, by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Lengthen your lifespan by drinking milk: Rumenic acid, a conjugated linoleic acid found abundantly in cow’s milk, may increase life span, via up-regulation of its target gene BubR1
From research findings to Therapeutic Opportunity:
It has been suggested that drinking milk can lessen the chances of dying from coronary heart disease and stroke by about 15-20%. However, the molecular basis of which remains unclear. This study suggests, for the first time, that Rumenic acid, a conjugated linoleic acid found abundantly in cow’s milk, may function as a longevity promoter. Rumenic acid, by increasing the expression of its target gene, it may: (a) increase the expression of BuBR1; (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (fig. 1).
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Figure 1. Rumenic acid may extend mammalian life span via up regulation of BuBR1 and down regulation of p70 S6 Kinase
Figure 2. The chemical structure of Rumenic acid. It is found abundantly in cow’s milk. It functions as a longevity-promoter by increasing the expression of BuBR1 and other longevity-promoting genes.
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $500#
Undisclosed mechanistic information: How Rumenic acid increases the expression of BubR1 and extends mammalian life-span
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Lengthen your lifespan by drinking milk: Rumenic acid, a conjugated linoleic acid found abundantly in cow’s milk, may increase life span, via up-regulation of its target gene BubR1, 21/March/2018, 10.47 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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