What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the journal “EMBO”, by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Lifespan extension therapy: Pyrroloquinoline quinone (PQQ), isolated from Kiwifruits, increases life span via up-regulation of its target gene BubR1
What is known?
Both Hesperidin and Naringenin have been shown to possess anti-hyperglycemic property. However, the exact mechanism of action is far from clear. I had published earlier that Hesperidin and Naringenin, individually, may improve insulin sensitivity, promote resistance to bone, immune and motor dysfunction and extend lifespan through down regulation of p70 S6 Kinase.
From research findings to therapeutic opportunity:
This study suggests, for the first time, a role for Pyrroloquinoline quinone (PQQ) in lifespan extension. A therapeutic mix encompassing Pyrroloquinoline quinone (PQQ), by increasing the expression of its target gene, it may: (a) increase the expression of BuBR1; (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (Fig. 1).
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Figure 1. A therapeutic mix encompassing Pyrroloquinoline quinone (PQQ) may extend mammalian life span via up regulation of BuBR1 and down regulation of p70 S6 Kinase
Figure 2. The chemical structures of Pyrroloquinoline quinone (PQQ). PQQ may function as a longevity-promoting agent through induction of BuBR1.
Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus, pharmacological formulations encompassing “Pyrroloquinoline quinone (PQQ) or its analogues, either alone or in combination with other drugs“ may be used to extend the lifespan of an individual (fig. 1).
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $500#
Undisclosed mechanistic information: How Pyrroloquinoline quinone (PQQ) increases the expression of BubR1 and extends mammalian life-span
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# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Lifespan extension therapy: Pyrroloquinoline quinone (PQQ), isolated from Kiwifruits, increases life span via up-regulation of its target gene BubR1, 15/December/2017, 10.05 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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