Mechanistic insights into how analgesic agent Methadone attenuates pain: Methadone(trade name: Dolphine & Methadose), an analgesic drug used mainly in post-operative pain relief, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 27/September/2018, 12.43 am