Mechanistic insights into how anesthetic agent Hyoscine may deteriorate memory, learning, and cognition: Hyoscine (trade name: Transdermscop and others), a local anesthetic agent, decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes, 22/November/2018, 10.56 pm