Introduction: What they say
A study from the Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California, USA; and Koch Institute at MIT, 500 Main Street, Cambridge, USA shows that “Fasting-Mimicking Diet Promotes Ngn3-Driven ß-Cell Regeneration to Reverse Diabetes.” This research paper was published in the 23 February 2017 issue of the journal “Cell” [One of the best research journals in Biology with an I.F of 28 plus] by Prof. and Director of Longevity institute Valter Longo, Cheng CW and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular Hydrogen-based regenerative therapy for reversing diabetes: Hydrogen-rich water increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene
From Significance of the study to Public health relevance:
Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) Diabetes is going to be one of the top 10 causes of death by 2030; (3) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.
What is known?
It has recently been shown that fasting mimicking diet (FMD):(1) increases the expression of Sox17, Pdx-1 (Pancreatic And Duodenal Homeobox 1), and Ngn3 (Neurogenin-3) sequentially; (2) promotes regeneration of insulin-producing ß cells; (3) decreases Protein Kinase A and mTOR activity; (4) increases reprogramming proteins Sox2 and Ngn3 expression; (5) increases insulin secretion; and (6) promotes glucose homeostasis, suggesting that FMD: (i) promotes reprogramming of pancreatic cells to restore insulin secretion in islets; and (ii) can reverse both T1D and T2D.
From Research findings to Therapeutic opportunity:
This study suggests, for the first time, a Hydrogen-rich water-based regenerative therapy for T1DM and TIIDM.
Hydrogen-rich water, by increasing the expression of its target genes, it may increase the expression of Sox17, Ngn3, Sox2, Pdx-1, NKX6.1, Pax6, INS etc. (Fig. 1). Thereby, it may: (1) decrease the expression of mTOR; (2) increase generation of insulin-producing ß cells; (3) increase insulin secretion; and (4) promote glucose homeostasis, suggesting that Hydrogen-rich water–may replace the need for FMD or function as an effective alternative to FMD–may find its use in clinic in attenuating and/or reversing both T1D and T2D, as it turns on most of the reprogramming/insulin-producing genes turned by the FMD (Figs.1-2).
Thus, physicians/diabetologists may consider adopting Hydrogen-rich water therapy in the treatment of T1DM and T2DM. Taken together, Hydrogen-rich water therapy may be used to reverse T1D and T2D (Fig2).
Figure 1. Mechanistic insights into how hydrogen-rich water, by turning on the expression of Ngn3, NKX6.1, Pax6, and INS among others genes, may promote reprogramming of pancreatic cells to restore insulin secretion in islets; and reverse both T1DM and T2DM.
Figure 2. Hydrogen-rich water ionizer. Hydrogen-rich water may aid in reversal of T1DM and TIIDM through induction of its target genes (Image courtesy: https://www.greenfuelh2o.com/Hydrogen_rich_water_bottle_ionizer_p/h2bottle2.htm)
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does Hydrogen-rich water increase the expression of Sox17, Sox2, Pdx-1, and Ngn3 to reprogram of pancreatic cells, to restore insulin secretion?
Amount: $ 750#
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References:
Web: http://genomediscovery.org or http://newbioideas.com
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Molecular Hydrogen-based regenerative therapy for reversing diabetes: Hydrogen-rich water increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 28/June/2017, 12.11 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org