What they say: Introduction:
The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function.
What we say:
In connection with the finding presented above, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product Anti-telomerase cancer therapy: Hesperetin, found in citrus fruits, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene
Significance:
Given that cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; (iii) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (iv) a way to effectively treat and eradicate metastatic progression of cancer.
From Research Findings to Therapeutic opportunity:
Hesperetin, by increasing the expression of its target gene, it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1). Remarkably, over 90% human tumors overexpress telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.
Citrus peel: Citrus peel extract inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase
Figure 1. Hesperetin
Citrus fruits
Citrus fruits
Thus, this study suggests that pharmacological formulations encompassing “Hesperetin or its analogs“ may be used to treat human cancers.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, L., Natural product Anti-telomerase cancer therapy: Hesperetin, found in citrus fruits, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 4/November/2016, 10.35 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Courtesy: When you cite drop us a line at info@genomediscovery.org
Web: http://genomediscovery.org or http://newbioideas.com
Amount: $100#
Undisclosed information: How Hesperetin suppresses the expression of Tripeptidyl Peptidase 1 (TPP1)
Satisfaction-guaranteed-if-not-refunded
# Research cooperation