What they say:
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Myocardial Infarction: Abelmoschus M. flower extract improves myocardial function after myocardial infarction via up-regulation of PNUTS
Significance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free drug.
From Research Findings to Therapeutic Opportunity:
This study suggests a natural product-based cardiac regeneration therapy. Abelmoschus M. flower extract, by increasing the expression of its target gene, it may increase the expression of PNUTS. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardiomyocyte survival/regeneration.
Abelmoschus M. extract promotes Cardiomyocyte survival and protects against myocardial infarction via up-regulation of PNUTS
Thus, by treating myocardial patients with Abelmoschus M. flower extract, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that pharmacological formulations encompassing “Abelmoschus M. flower extract or an active compound isolated from it” may be used to improve cardiac function after myocardial infarction.
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Web:http://genomediscovery.org or http://newbioideas.com
To cite: Boominathan, L., Natural product therapy for Myocardial Infarction: Abelmoschus M. flower extract improves myocardial function after myocardial infarction via up-regulation of PNUTS, 4/November/2016, 8.31 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Abelmoschus M. flower extract increases the expression of PNUTS
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